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甲精结合蛋白17抗体
产物名称 | 英文名称 | 货号 |
甲精结合蛋白17抗体 | FBP17 | GOY-01K0701 |
商品属性：
英文名称: FBP17
中文名:甲精结合蛋白17抗体
别 名；FBP1; FBP17;
FNBP1; FNBP1_HUMAN; Formin binding protein 1; Formin binding protein 17; Formin-binding
protein 1; Formin-binding protein 17; hFBP17; KIAA0554; MGC126804.
研究领域；细胞生物 信号转导 转录调节因子 结合蛋白 上皮细胞
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Dog, Cow, Horse, Zebrafish, Sheep, )
产物应用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；71kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human FBP17: 331-430/617
亚 型；IgG
纯化方法；affinity purified
by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
FNBP1 is a 617 amino acid protein that localizes
to a variety of locations within the cell, including the cytoplasm,
cytoskeleton, lysosome and the cell cortex, and contains one FCH domain, one
REM repeat and one SH3 domain. Expressed at high levels in respiratory,
reproductive and urinary systems, as well as in brown adipose tissue and
epithelial cells of the gastrointestinal tract, FNBP1 interacts with Rho 7
and links the Actin cytoskeleton with Rho 7 signaling, playing a crucial role
in membrane tubulation and cytoskeletal reorganization during endocytosis.
Additionally, FNBP1, which exists as four alternatively spliced isoforms,
enhances Actin polymerization and promotes membrane invagination and the
formation of tubules. Chromosomal aberrations in the FNBP1 gene are
associated with acute leukemias, suggesting a role for defective FNBP1 in
carcinogenesis. May act as a link between RND2 signaling and
regulation of the actin cytoskeleton (By similarity). Required to coordinate
membrane tubulation with reorganization of the actin cytoskeleton during
endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate
and phosphatidylserine and promotes membrane invagination and the formation
of tubules. Also enhances actin polymerization via the recruitment of
WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization
may promote the fission of membrane tubules to form endocytic vesicles. May
be required for the lysosomal retention of FASLG/FASL. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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